Piezo2 channel–Merkel cell signaling modulates the conversion of touch to itch
The somatosensory system relays many signals ranging from light touch to pain and itch.
Touch is critical to spatial awareness and communication. However, in disease states …
Touch is critical to spatial awareness and communication. However, in disease states …
Merkel cells are essential for light-touch responses
SM Maricich, SA Wellnitz, AM Nelson, DR Lesniak… - Science, 2009 - science.org
The peripheral nervous system detects different somatosensory stimuli, including pain,
temperature, and touch. Merkel cell-neurite complexes are touch receptors composed of …
temperature, and touch. Merkel cell-neurite complexes are touch receptors composed of …
Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle
Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin.
Although scratching transiently relieves acute itch through activation of mechanoreceptors, it …
Although scratching transiently relieves acute itch through activation of mechanoreceptors, it …
Merkel cells and neurons keep in touch
SH Woo, EA Lumpkin, A Patapoutian - Trends in cell biology, 2015 - cell.com
The Merkel cell–neurite complex is a unique vertebrate touch receptor comprising two
distinct cell types in the skin. Its presence in touch-sensitive skin areas was recognized more …
distinct cell types in the skin. Its presence in touch-sensitive skin areas was recognized more …
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
S Maksimovic, M Nakatani, Y Baba, AM Nelson… - Nature, 2014 - nature.com
Touch submodalities, such as flutter and pressure, are mediated by somatosensory afferents
whose terminal specializations extract tactile features and encode them as action potential …
whose terminal specializations extract tactile features and encode them as action potential …
Uncovering the cells and circuits of touch in normal and pathological settings
The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …
the nature of our physical environment. Primary sensory neurons provide the basis for this …
[HTML][HTML] The touch dome defines an epidermal niche specialized for mechanosensory signaling
YS Doucet, SH Woo, ME Ruiz, DM Owens - Cell reports, 2013 - cell.com
In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the
perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from …
perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from …
Merkel cells activate sensory neural pathways through adrenergic synapses
Epithelial-neuronal signaling is essential for sensory encoding in touch, itch, and
nociception; however, little is known about the release mechanisms and neurotransmitter …
nociception; however, little is known about the release mechanisms and neurotransmitter …
Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses
R Ikeda, M Cha, J Ling, Z Jia, D Coyle, JG Gu - Cell, 2014 - cell.com
Sensory systems for detecting tactile stimuli have evolved from touch-sensing nerves in
invertebrates to complicated tactile end organs in mammals. Merkel discs are tactile end …
invertebrates to complicated tactile end organs in mammals. Merkel discs are tactile end …
Mechanotransduction in epidermal Merkel cells
M Nakatani, S Maksimovic, Y Baba… - Pflügers Archiv-European …, 2015 - Springer
The cellular and molecular basis of vertebrate touch reception remains least understood
among the traditional five senses. Somatosensory afferents that innervate the skin encode …
among the traditional five senses. Somatosensory afferents that innervate the skin encode …