The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer

W Zeng, X Long, PS Liu, X Xie - International Journal of Cancer, 2023 - Wiley Online Library
Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …

The molecular mechanisms of regulating oxidative stress‐induced Ferroptosis and therapeutic strategy in tumors

J Zhu, Y Xiong, Y Zhang, J Wen, N Cai… - Oxidative Medicine …, 2020 - Wiley Online Library
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis,
necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron‐dependent …

[HTML][HTML] Metabolic regulation of ferroptosis in the tumor microenvironment

NE Mbah, CA Lyssiotis - Journal of Biological Chemistry, 2022 - ASBMB
Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by
impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid …

[HTML][HTML] The role of ferroptosis in cancer development and treatment response

B Lu, XB Chen, MD Ying, QJ He, J Cao… - Frontiers in …, 2018 - frontiersin.org
Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell
death, which is a distinct regulated cell death comparing to other cell death. The lethal …

[HTML][HTML] Regulatory pathways and drugs associated with ferroptosis in tumors

D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

[HTML][HTML] Emerging mechanisms and targeted therapy of ferroptosis in cancer

H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang… - Molecular Therapy, 2021 - cell.com
Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response

Y Yao, Y Shi, Z Gao, Y Sun, F Yao… - American Journal of …, 2022 - journals.physiology.org
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid
peroxides in an iron-dependent manner. Ferroptotic cell death is modulated by many …

[HTML][HTML] Ferroptosis-mediated crosstalk in the tumor microenvironment implicated in cancer progression and therapy

Y Liu, C Duan, R Dai, Y Zeng - Frontiers in cell and developmental …, 2021 - frontiersin.org
Ferroptosis is a recently recognized form of non-apoptotic regulated cell death and usually
driven by iron-dependent lipid peroxidation and has arisen to play a significant role in …

[HTML][HTML] Targeting ferroptosis pathway to combat therapy resistance and metastasis of cancer

X Liu, Y Zhang, X Wu, F Xu, H Ma, M Wu… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is an iron-dependent regulated form of cell death caused by excessive lipid
peroxidation. This form of cell death differed from known forms of cell death in morphological …

[HTML][HTML] Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

F Pu, F Chen, Z Zhang, D Shi, B Zhong, X Lv… - Genes & …, 2022 - Elsevier
The treatment of cancer mainly involves surgical excision supplemented by radiotherapy
and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing …