Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Obesity is a major health concern that increases the risk for insulin resistance, type 2
diabetes (T2D), and cardiovascular disease. Thus, an enormous research effort has been …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and
consumption. Adipocytes, the key components of the adipose tissue, have unique ability to …

Ceramide synthases (CerS) are central enzymes required for the de-novo synthesis of
ceramides and other sphingolipids. They catalyze the addition of different acyl-chains to a …

Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and
cardiovascular disease. Recently, one particular lipid class has been shown to influence the …

Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …