Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly
influenced by the surrounding microenvironment of the tumor. Therefore, the ability to …

The purpose of this review is to highlight the recent mechanistic developments elucidating
the role of matrix metalloproteinases (MMPs) in tumour invasion and metastasis. The ability …

Matrix metalloproteinases (MMPs) are the group of enzymes that belong to the family of zinc
dependent endopeptidases. These proteases degrade collagen and other important …

The microenvironment or stroma immediately surrounding tumor cells consists of a three‐
dimensional extracellular matrix (ECM) and stromal cells such as fibroblasts and …

Cancer cells evolve in the tumor microenvironment (TME) by the acquisition of
characteristics that allow them to initiate their passage through a series of events that …

The increasing diversity in both substrates and functions of matrix metalloproteinases
(MMPs) makes these enzymes central regulators in the complex tumor ecosystem …

Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
capable of degrading numerous extracellular matrix (ECM) components thus participating in …

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to
unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis …