As the body's integumentary system, the skin is vulnerable to injuries. The subsequent
wound healing processes aim to restore dermal and epidermal integrity and functionality. To …

Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue
damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial …

Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control
inflammation and mediate tissue-specific functions. The skin of mice and humans contain a …

Regulatory T cells (Tregs) use multiple mechanisms to attenuate inflammation and prevent
autoimmunity. Tregs residing in peripheral (ie, nonlymphoid) tissues have specialized …

Summary Foxp3+ CD 4+ regulatory T (Treg) cells are a subset of immune cells that function
to regulate tissue inflammation. Skin is one of the largest organs and is home to a large …

The skin is the largest organ in the body and one of the primary barriers to the environment.
In order to optimally protect the host, the skin is home to numerous immune cell subsets that …

Regulatory T cells (Tregs) restrain excessive immune responses and dampen inflammation.
In addition to this classical immune suppressive role, Tregs in non-lymphoid tissues also …

Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease
mediated by the interplay of T cells and polymorphonuclear granulocytes. Although …

Healing of skin wounds is orchestrated by various types of immune cells, but little is known
about the role of FoxP3+ regulatory T cells (Tregs) in this process. Here, we determined if …

The identification of stem cells and growth factors as well as the development of biomaterials
hold great promise for regenerative medicine applications. However, the therapeutic efficacy …