YB-1 is a member of the cold shock domain family of proteins that is important for signaling
DNA damage and cell proliferation. YB-1 is induced by DNA damage and can also …

p73 shares high sequence homology with the tumor suppressor p53. Like p53, ectopic
overexpression of p73 induces cell cycle arrest and/or apoptosis, and these biological …

Specific protein-protein interactions are involved in a large number of cellular processes and
are mainly mediated by structurally and functionally defined domains. Here we report that …

We recently reported that c-Myc represses the transcription of platelet-derived growth factor
(PDGF) β-receptor (Izumi, H., Molander, C., Penn, LZ, Ishisaki, A., Kohno, K., and Funa …

The newly discovered p73 gene encodes a nuclear protein that has high homology with
p53. Furthermore, ectopic expression of p73 in p53+/+ and p53−/− cancer cells recapitulates …

The transcriptional coactivator Yes-associated protein (YAP) has been shown to interact with
and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show that …

The transcription factor p73 is a structural homologue of p53 and plays an important role in
tumorigenesis, differentiation and development. However, the regulation of p73 pathway has …

p73, a member of the p53 family, is expressed from two separate promoters, generating TA
and ΔN variants. Each variant potentially encodes at least seven alternatively spliced …

The identification of upstream pathways that signal to TP73 is crucial for understanding the
biological role of this gene. Since some evidence suggests thatTP73 might play a role in …

The transcription factor p73 belongs to the p53 family of proteins and can transactivate a
number of target genes in common with p53. Here, we characterized the interaction of the …