Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …

During fasting and many systemic diseases, muscle undergoes rapid loss of protein and
functional capacity. To define the transcriptional changes triggering muscle atrophy and …

Skeletal muscle atrophy has extreme adverse consequences. Molecular mechanisms that
mediate the process of atrophy are not well defined. Recent studies have focused on diverse …

Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional
consequences. While the initiating physiological event leading to atrophy seems to be the …

Skeletal muscle atrophy proceeds through a complex molecular signaling network that is
just beginning to be understood. Here, we discuss examples of recently identified molecular …

We previously identified a common set of genes, termed atrogenes, whose expression is
coordinately induced or suppressed in muscle during systemic wasting states (fasting …

Skeletal muscle adapts to loading; atrophying when exposed to unloading on Earth or in
spaceflight. Significant atrophy (decreases in muscle fiber cross-section of 11-24%) in …

Loss of muscle proteins and the consequent weakness has important clinical consequences
in diseases such as cancer, diabetes, chronic heart failure, and in aging. In fact, excessive …

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic
therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by …

Muscular inactivity leads to atrophy, weakness, and decreased fatigue resistance. In order to
provide a window into the dynamic processes that underlie muscle atrophy, we performed …