Low birth weight is associated with an increased risk of hypertension and renal dysfunction
at adulthood. Such an association has been shown to involve a reduction of nephron …

Various antenatal events impair nephrogenesis in humans as well as in several animal
models. The consecutive low nephron endowment may contribute to an increased risk for …

Accelerated growth in early infancy has been associated with later cardiovascular and
metabolic diseases. We investigated the influence of overnutrition during neonatal periods …

Impaired growth in utero predicts a low nephron number and high blood pressure later in life
as does slowed or accelerated growth after a normal birth weight. We measured the effects …

Background: Intrauterine growth restriction (IUGR) and postnatal nutrition are risk factors for
cardiovascular and renal diseases in both humans and animals. The long-term renal effects …

Epidemiological and experimental studies show that the risk of cardiovascular and
metabolic diseases at adulthood is inversely related to the weight at birth. Although with less …

Background: Our previous studies demonstrated that maternal protein-restricted (low-
protein, LP) 16-week-old offspring had pronounced nephron number reduction and arterial …

Many studies report sexual dimorphism in the fetal programming of adult disease. We
hypothesized that there would be differences in the age-related decline in renal function …

It has been proposed that low birth weight (LBW) results in a reduction in glomerular number
that may, in turn, predispose an individual to develop hypertension in adulthood. Glomerular …

Uteroplacental insufficiency in the rat restricts fetal growth, impairs mammary development,
compromising postnatal growth; and increases adult BP. The roles of prenatal and postnatal …