It has long been thought that sequence-specific PTGS required a nucleic acid polymer to
guide mRNA cleavage.[35] The presence of an antisense RNA species complementary to …

An efficient mechanism for the sequence‐specific inhibition of gene expression is RNA
interference. In this process, double‐stranded RNA molecules induce cleavage of a selected …

Improved protecting‐group strategies are used in two successful methods for the synthesis
of oligoribonucleotides. The effective production of these compounds is of growing …

Since the first unequivocal description of RNA interference (RNAi) in 1998, it has remained
one of the hottest topics under investigation, culminating in the award of a Nobel Prize to its …

RNA learns from antisense | Nature Chemical Biology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

I would like to thank the Nobel Assembly of the Karolinska Institute for the opportunity to
describe some recent work on RNA‐triggered gene silencing. First a few disclaimers …

In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism
in eukaryotic gene expression. The realization that changes in the levels of microRNAs are …

We investigated the mechanism of RNA interference (RNAi) in human cells. Here we
demonstrate that the status of the 5′ hydroxyl terminus of the antisense strand of a siRNA …

The biology of RNA interference has greatly facilitated analysis of loss-of-function
phenotypes, but correlating these phenotypes with small-molecule inhibition profiles is not …

Now that the sequencing of many genomes has been completed, the basic challenges are
finding the genes and predicting their functions. Up until now, a large information gap has …