Glutathione (GSH) is present ubiquitously, and its role as a crucial cellular antioxidant in
tissues, including the retina, is well established. GSH's antioxidant function arises from its …

purpose. Glutathione (GSH) plays a key role in protection against oxidative stress. l-Cysteine
is thought to be rate-limiting for the synthesis of glutathione (GSH) and therefore may be a …

Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

BACKGROUND: Mitochondria are the powerhouse of mammalian cells and the main source
of reactive oxygen species (ROS) associated with oxygen consumption. In addition, they …

Thioltransferase (or Grx) belongs to the oxidoreductase family and is known to regulate
redox homeostasis in cells. Mitochondrial Grx2 is a recent discovery, but its function is …

Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Glutathione (GSH) protects against oxidative damage in many tissues, including retinal
pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and …

Diabetic retinopathy (DR) is a major cause of blindness in adult, and the accumulation of
advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal …

High oxygen tension, exposure to light, and the biochemical events of vision generate
significant oxidative stress in the retina and the retinal pigment epithelium (RPE) …