The Th2 cytokines, interleukin (IL)-4 and-13, are structurally and functionally related. They
regulate immune responses and the immune microenvironment, not only under normal …

Abstract Interleukin‐6 (IL‐6) plays a major role in the response to injury or infection and is
involved in the immune response, inflammation, and hematopoiesis. Its deregulation …

The Th2 cytokines interleukin (IL)-4 and-13 are acknowledged regulators of lymphocyte
proliferation and activation. They have also been well studied in the regulation of various …

Abstract Interleukin 13 receptor alpha 2 (IL13Rα2) is increasingly recognized as a relevant
player in cancer invasion and metastasis. Despite being initially considered a decoy …

Interleukin (IL)-4 and-13 are structurally and functionally related cytokines sharing common
receptor subunits. They regulate immune responses and, moreover, are involved in the …

Interleukin 13 receptor α2 (IL-13Rα2) chain is highly expressed on some tumor cell lines
and primary cell cultures. This receptor chain plays an important role in ligand binding and …

Despite advances in diagnosis and treatment, survival rates for patients with head and neck
cancer have remained unchanged for the last 30 years. In an attempt to develop novel …

The high-affinity human interleukin-7 (IL-7) R is a heterodimeric complex consisting of the IL-
7Rα and common interleukin-2 receptor γ (IL-2Rγc) chains. Activation of the IL-7R complex …

Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane
receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid …