Huntington's disease: a clinical review

P McColgan, SJ Tabrizi - European journal of neurology, 2018 - Wiley Online Library
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Huntington's disease: clinical presentation and treatment

MJU Novak, SJ Tabrizi - International review of neurobiology, 2011 - Elsevier
Huntington's disease (HD) is a devastating inherited neurodegenerative disease
characterized primarily by progressive motor, cognitive, and psychiatric symptoms. It is …

Current and possible future therapeutic options for Huntington's disease

MW Ferguson, CJ Kennedy… - Journal of central …, 2022 - journals.sagepub.com
Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …

Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments

E Roze, F Saudou, J Caboche - Current opinion in neurology, 2008 - journals.lww.com
Pathophysiology of Huntington's disease: from huntingtin fun... : Current Opinion in Neurology
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments …

Huntington's disease: Diagnosis and management

TB Stoker, SL Mason, JC Greenland, ST Holden… - Practical …, 2022 - pn.bmj.com
Huntington's disease (HD) is an inherited neurodegenerative disease characterised by
neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and …

Huntington disease

GP Bates, R Dorsey, JF Gusella, MR Hayden… - Nature reviews Disease …, 2015 - nature.com
Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Huntington disease

R Ghosh, SJ Tabrizi - Handbook of clinical neurology, 2018 - Elsevier
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-
dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …

Huntington's disease: pathomechanism and therapeutic perspectives

G Gárdián, L Vécsei - Journal of Neural Transmission, 2004 - Springer
Huntington's disease is an autosomal dominantly inherited progressive neurodegenerative
disorder. The mutant gene has been localised to chromosome 4p16. 3. The gene product …

Huntington's disease: New frontiers in therapeutics

L Pan, A Feigin - Current Neurology and Neuroscience Reports, 2021 - Springer
Abstract Purpose of Review This article describes and discusses new potential disease-
modifying therapies for Huntington's disease that are currently in human clinical trials as well …

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies

M Borrell-Pages, D Zala, S Humbert… - Cellular and Molecular Life …, 2006 - Springer
Huntington's disease (HD) is a neurodegenerative disorder that usually starts in middle age
and is characterized by involuntary movements (chorea), personality changes and …