The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

G Neufeld, O Kessler - Nature Reviews Cancer, 2008 - nature.com
The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …

Semaphorins in cancer: biological mechanisms and therapeutic approaches

M Rehman, L Tamagnone - Seminars in cell & developmental biology, 2013 - Elsevier
The hallmarks of cancer include multiple alterations in the physiological processes occurring
in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These …

Semaphorin signaling in cancer cells and in cells of the tumor microenvironment–two sides of a coin

L Capparuccia, L Tamagnone - Journal of cell science, 2009 - journals.biologists.com
Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

The role of the semaphorins in cancer

G Neufeld, Y Mumblat, T Smolkin… - Cell Adhesion & …, 2016 - Taylor & Francis
The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

The emerging role of class-3 semaphorins and their neuropilin receptors in oncology

P Nasarre, RM Gemmill, HA Drabkin - OncoTargets and therapy, 2014 - Taylor & Francis
The semaphorins, discovered over 20 years ago, are a large family of secreted or
transmembrane and glycophosphatidylinositol-anchored proteins initially identified as axon …

The role of semaphorins and their receptors in vascular development and cancer

C Gu, E Giraudo - Experimental cell research, 2013 - Elsevier
Semaphorins (Semas) are a large family of traditional axon guidance molecules. Through
interactions with their receptors, Plexins and Neuropilins, Semas play critical roles in a …

Semaphorins in angiogenesis and tumor progression

G Neufeld, AD Sabag… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
The semaphorins were initially described as axon guidance factors, but have recently been
implicated in a variety of physiological and developmental functions, including regulation of …

[HTML][HTML] Class-3 semaphorins and their receptors: potent multifunctional modulators of tumor progression

S Toledano, I Nir-Zvi, R Engelman, O Kessler… - International journal of …, 2019 - mdpi.com
Semaphorins are the products of a large gene family containing 28 genes of which 21 are
found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate …

[PDF][PDF] Semaphorins in cancer

G Neufeld, N Shraga-Heled, T Lange… - Front Biosci, 2005 - researchgate.net
The semaphorins are the products of a large family of genes currently containing more than
30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain …

Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

J Rieger, W Wick, M Weller - Glia, 2003 - Wiley Online Library
Semaphorins comprise a family of molecules implicated in the guiding of growing axons and
neuronal progenitor cells. Further, semaphorins have been suggested to play a role in …