Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing
adenosine at A 1 and A 2A receptors, and perhaps through interactions with other …

Caffeine, a widely consumed adenosine A 1 and A 2A receptor antagonist, is valued as a
psychostimulant, but it is also anxiogenic. An association between a variant within the …

The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also
thought to be involved in the regulation of anxiety. In this study, we examined the association …

Data from clinical and behavioral pharmacological studies have implicated adenosine in
anxiety behaviors, while genetic studies have suggested that adenosine receptors may be …

Caffeine is the most widely used stimulant in Western countries. Some people voluntarily
reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice …

Caffeine's ergogenic effects on exercise performance are generally explained by its ability to
bind to adenosine receptors. ADORA2A is the gene that encodes A2A subtypes of …

Background: Caffeine is the most widely consumed stimulant in the world, and individual
differences in response to its stimulating effects may explain some of the variability in …

ADORA2A has been shown to be responsible for the wakefulness-promoting effect of
caffeine and the 1976T> C genotype (SNP rs5751876, formerly 1083T> C) to contribute to …

Adenosine A2A receptors are suggested to play an important role in different brain circuits
and pathways involved in anxiety reactions. A variant within the corresponding ADORA2A …

Emerging research has demonstrated that genetic variation may impact physiological
responses to caffeine consumption. The purpose of the present review was to systematically …