Rationale: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation
under physiological and pathophysiological conditions. It dilates arterioles by activating …

Rationale: Hydrogen peroxide (H2O2) serves as a key endothelium-derived hyperpolarizing
factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise …

Hydrogen peroxide (H2O2) and voltage-dependent K+ (KV) channels play key roles in
regulating coronary blood flow in response to metabolic, ischemic, and paracrine stimuli …

Previously, we demonstrated that coronary vasodilation in response to hydrogen peroxide
(H2O2) is attenuated by 4-aminopyridine (4-AP), an inhibitor of voltage-gated K+ (KV) …

The connection between metabolism and flow in the heart, metabolic dilation, is essential for
cardiac function. We recently found redox‐sensitive Kv1. 5 channels play a role in coronary …

Small arteries play an essential role in the regulation of blood pressure and organ-specific
blood flow by contracting in response to increased intraluminal pressure, ie, the myogenic …

Hyperglycemia is associated with impaired endothelium-dependent dilation that is due to
quenching of NO by superoxide (O2·−). In small coronary arteries (CAs), dilation depends …

Hydrogen peroxide (H2O2) is a proposed endothelium-derived hyperpolarizing factor and
metabolic vasodilator of the coronary circulation, but its mechanisms of action on vascular …

We previously reported that exercise training drives enhanced agonist-stimulated hydrogen
peroxide (H2O2) levels and restores endothelium-dependent dilation via an increased …

By hyperpolarizing arterial smooth muscle, voltage-gated, Ca2+-independent K+ (Kv)
channels decrease calcium influx and thus oppose constriction. However, the molecular …