Background Spinal cord has been considered the main target of damage in hereditary
spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected …

Background Although the typical inheritance of spastic paraplegia 7 is recessive, several
reports have suggested that SPG7 variants may also cause autosomal dominant hereditary …

Hereditary spastic paraplegias (HSP) are genetically and clinically heterogeneous
neurodegenerative disorders. Most MR studies on HSP include very heterogeneous …

Background Next‐generation sequencing‐based molecular assessment has benefited the
diagnosis of hereditary spastic paraplegia (HSP) subtypes. However, the clinical and …

Hereditary spastic paraplegias (HSP) are genetically and clinically heterogeneous
neurodegenerative disorders. The purpose of this study was to assess the genotype and …

Aims The hereditary spastic paraplegias (HSP s) are a heterogeneous group of disorders
characterized by spasticity in the lower limbs. We provide an overview of HSP with an …

Background Familial hereditary spastic paraplegia (HSP)‐SPAST (SPG4) typically presents
with a pure HSP phenotype. Objective The aim of this study was to delineate the genotypic …

Background: Autosomal recessive hereditary spastic paraplegia with thin corpus callosum is
a neurodegenerative disorder characterized by spastic paraparesis, cognitive impairment …

Autosomal‐dominant spinocerebellar ataxias, autosomal‐recessive spinocerebellar ataxias,
and hereditary spastic paraplegias have traditionally been designated in separate …

Background: The aim of this study was to describe a case of hereditary spastic paraplegia
(HSP) resulting from SPG 11 mutations, presenting with a complex phenotype of dopa …