sialyllactose is one of the abundant components in human milk oligosaccharides (HMOs)
that protect infants from various viral infections in early stages of immune system …

Sialyllactose (SL) is a representative human milk oligosaccharide (HMO) of human breast
milk. The roles of SL in infant brain development and immunity have been reported in …

Oligosialic and polysialic acid (oligoSia and polySia) of the glycocalyx of neural and immune
cells are linear chains, in which the sialic acid monomers are α2. 8-glycosidically linked …

Human sialic acid–binding immunoglobulin-like lectin 14 (Siglec-14) is a glycan-recognition
protein that is expressed on myeloid cells, recognizes bacterial pathogens, and elicits pro …

Abstract The β-galactoside α2-6-sialyltransferase 1 (ST6Gal-I) is the principal
sialyltransferase responsible for the addition of α2-6-sialic acid to the termini N-glycans on …

The overexpression of sialic acids on glycans, called hypersialylation, is a common
alteration found in cancer cells. Sialylated glycans can enhance immune evasion by …

The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …

To analyze the binding specificity of a sialic acid–recognizing lectin, sialic acid-binding Ig-
like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3 …

Siglecs recognize the sialic acid moiety and regulate various immune responses. In the
present study, we compared the expression levels of Siglecs in human monocytes and …

The SLC7A11/xCT cystine and glutamate antiporter has emerged as an attractive target for
cancer therapy due to its selective overexpression in multiple cancers and its role in …