[HTML][HTML] Dual-energy X-ray absorptiometry measures of lean body mass as a biomarker for progression in boys with Duchenne muscular dystrophy

SP Sherlock, J Palmer, KR Wagner, HZ Abdel-Hamid… - Scientific reports, 2022 - nature.com
We evaluated whether whole-body dual-energy X-ray absorptiometry (DXA) measures of
lean body mass can be used as biomarkers for disease progression and treatment effects in …

Influence of a two-year steroid treatment on body composition as measured by dual X-ray absorptiometry in boys with Duchenne muscular dystrophy

C Vuillerot, P Braillon, S Fontaine-Carbonnel… - Neuromuscular …, 2014 - Elsevier
Steroids are nowadays routinely used as a long-term treatment in Duchenne muscular
dystrophy (DMD). Their effects on body composition were assessed using dual X-ray …

[HTML][HTML] Upper limb evaluation in Duchenne muscular dystrophy: fat-water quantification by MRI, muscle force and function define endpoints for clinical trials

V Ricotti, MRB Evans, CDJ Sinclair, JW Butler… - PLoS …, 2016 - journals.plos.org
Objective A number of promising experimental therapies for Duchenne muscular dystrophy
(DMD) are emerging. Clinical trials currently rely on invasive biopsies or motivation …

Observations of body mass index in Duchenne muscular dystrophy: a longitudinal study

ZE Davidson, MM Ryan, AJ Kornberg… - European journal of …, 2014 - nature.com
Results: Medical records (n= 193) were examined from which 75% were included for
analysis. The mean age of the cohort at the time of data collection was 11.9 years, with 72 …

Timed function tests, motor function measure, and quantitative thigh muscle MRI in ambulant children with Duchenne muscular dystrophy: A cross-sectional analysis

S Schmidt, P Hafner, A Klein, D Rubino-Nacht… - Neuromuscular …, 2018 - Elsevier
The development of new therapeutic agents for the treatment of Duchenne muscular
dystrophy has put a focus on defining outcome measures most sensitive to capture treatment …

Magnetic resonance imaging in Duchenne muscular dystrophy: longitudinal assessment of natural history over 18 months

KG Hollingsworth, P Garrood, M Eagle… - Muscle & …, 2013 - Wiley Online Library
ABSTRACT Introduction: In Duchenne muscular dystrophy (DMD), fat replacement of muscle
may be a useful endpoint in trials of therapy, although progression in different muscle …

[HTML][HTML] Discovery of metabolic biomarkers for Duchenne muscular dystrophy within a natural history study

SM Boca, M Nishida, M Harris, S Rao, AK Cheema… - PloS one, 2016 - journals.plos.org
Serum metabolite profiling in Duchenne muscular dystrophy (DMD) may enable discovery of
valuable molecular markers for disease progression and treatment response. Serum …

Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy

RJ Willcocks, WT Triplett, SC Forbes, H Arora… - Journal of …, 2017 - Springer
There is a pressing need for biomarkers and outcomes that can be used across disease
stages in Duchenne muscular dystrophy (DMD), to facilitate the inclusion of a wider range of …

[HTML][HTML] The relationship between obesity and clinical outcomes in young people with Duchenne muscular dystrophy

N Billich, J Adams, K Carroll, H Truby, M Evans… - Nutrients, 2022 - mdpi.com
Background: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular
disorder. Young people with DMD have high rates of obesity. There is emerging evidence …

[HTML][HTML] Quantitative magnetic resonance imaging measures as biomarkers of disease progression in boys with Duchenne muscular dystrophy: a phase 2 trial of …

SP Sherlock, J Palmer, KR Wagner… - Journal of …, 2022 - Springer
Duchenne muscular dystrophy (DMD) is a progressive, neuromuscular disorder caused by
mutations in the DMD gene that results in a lack of functional dystrophin protein. Herein, we …