Garmultin-A Incites Apoptosis in CB3 Cells Through miR-17-5p by Attenuating Poly (ADP-Ribose) Polymerase-1

J Qiu, L Chen, J Yang, KM Varier… - Dose …, 2022 - journals.sagepub.com
Background Leukemia accounts for a large number of deaths, worldwide, every year.
Treating this ailment is always a challenging job. Recently, oncogenic miRNA leading to …

MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers

JC Lee, DY Sim, HJ Lee, E Im, JB Choi… - Phytotherapy …, 2021 - Wiley Online Library
Since heat shock protein (HSP27) is a prognostic marker in cervical cancer, in the present
study, the apoptotic mechanism of lambertianic acid (LA) was investigated in human cervical …

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis

ZY Nie, MH Zhao, BQ Cheng, RF Pan, TR Wang… - Cancer Cell …, 2020 - Springer
Abstract Background The roots of Salvia miltiorrhiza are used in traditional Chinese
medicine (TCM) and have high medicinal value. Tanshinone IIA (Tan IIA) is the active …

[HTML][HTML] Bioinformatics-Guided Discovery of miRNAs Involved in Apoptosis Modulated by Parthenolide Combined with Vincristine in The NALM6 Cell Line

A Bahmei, S Namdari, M Yaghoubzad-Maleki… - Cell Journal …, 2024 - ncbi.nlm.nih.gov
Objective: Acute lymphoblastic leukemia (ALL) is a highly heterogeneous leukemia. Despite
the current improvement in conventional chemotherapy and high survival rates, the …

MiR-657/ATF2 Signaling Pathway Has a Critical Role in Spatholobus suberectus Dunn Extract-Induced Apoptosis in U266 and U937 Cells

HJ Lim, MN Park, C Kim, B Kang, HS Song, H Lee… - Cancers, 2019 - mdpi.com
Though Spatholobus suberectus Dunn (SSD) has been reported to have anti-virus, anti-
osteoclastogenesis, and anti-inflammation activities, its underlying anti-cancer mechanism …

Berberine induces apoptosis in non-small-cell lung cancer cells by upregulating miR-19a targeting tissue factor

Q Chen, J Shi, Z Ding, Q Xia, T Zheng… - Cancer Management …, 2019 - Taylor & Francis
Background Berberine (BBR) from the widely used Chinese herbal medicine Huanglian has
an array of pharmacological and biochemical properties, including anti-neoplastic activity …

Suppression of STAT3 phosphorylation and RelA/p65 acetylation mediated by MicroRNA134 plays a pivotal role in the apoptotic effect of Lambertianic acid

DY Sim, HJ Lee, JH Jung, E Im, J Hwang… - International Journal of …, 2019 - mdpi.com
As p300-mediated RelA/p65 hyperacetylation by signal transducers and activators of
transcription 3 (STAT3) is critical for NF-κB activation, in the current study, the apoptotic …

miR‐338‐3p Plays a Significant Role in Casticin‐Induced Suppression of Acute Myeloid Leukemia via Targeting PI3K/Akt Pathway

K Yu, J Wang, J Hou, L Zhang… - BioMed Research …, 2022 - Wiley Online Library
Objective. Casticin is generally used in traditional herbal medicine for its anti‐inflammatory
and anticarcinogenic pharmacological properties. Also, microRNAs are indispensable …

Ribosomal protein L5 mediated inhibition of c‐Myc is critically involved in sanggenon G induced apoptosis in non‐small lung cancer cells

JE Park, JH Jung, HJ Lee, DY Sim, E Im… - Phytotherapy …, 2021 - Wiley Online Library
Though Sanggenon G (SanG) from root bark of Morus alba was known to exhibit anti‐
oxidant and anti‐depressant effects, its underlying mechanisms still remain unclear. Herein …

Tanshinone IIa induces autophagy and apoptosis via PI3K/Akt/mTOR Axis in acute promyelocytic leukemia NB4 cells

Y Pan, L Chen, R Li, Y Liu, M Nan… - … and Alternative Medicine, 2021 - Wiley Online Library
Tanshinone IIa (TanIIa), an ingredient of Radix Salviae Miltiorrhizae, has an anticancer
effect on various solid tumors with high efficiency and low toxicity. Nonetheless, the …