Interferon gamma (IFNγ) is a potent cytokine that displays a variety of anti-viral, anti-
proliferative, immunomodulatory, apoptotic and anti-fibrotic functions. However, its clinical …

Liver fibrogenesis is a process tightly controlled by endogenous anti‐and pro‐fibrogenic
factors. Interferon gamma (IFNγ) is a potent antifibrogenic cytokine in vitro and might …

Liver fibrosis represents a scar formation process as a response to chronic injury and a
major cause of death worldwide. To date, no drug is available for this condition. Interleukin …

Cytokines, growth factors, and other locally produced mediators play key roles in the
regulation of disease progression. During liver fibrosis, these mediators orchestrate the …

Excessive accumulation of the extracellular matrix proteins primarily produced by activated
hepatic stellate cells (HSC) leads to liver fibrosis. To date, no successful therapeutic …

Hepatic stellate cells (HSCs), following transdifferentiation to myofibroblasts plays a key role
in liver fibrosis. Therefore, attempts to attenuate this myofibroblastic phenotype would be a …

The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α
for the treatment of chronic viral hepatitis. While the superior antiviral efficacy of pegIFN-α is …

Available pegylated interferon (PEG-IFN) products confer enhanced therapeutic efficacy
when compared with their IFN counterparts, and the added convenience of once-weekly …

Polyethylene glycol (PEG) moieties can be attached to proteins to improve their
pharmacological properties. Variables such as the molecular weight and conformation of …

Hepatic stellate cells play a crucial role in the pathogenesis of hepatic fibrosis. Thus,
pharmacological inhibition of pro-fibrotic activities of these cells might lead to an effective …