Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumor cells. This …

Metabolic alterations are one of the hallmarks of cancer, which has recently gained great
attention. Increased glucose absorption and lactate secretion in cancer cells are …

Cancer can be envisioned as a metabolic disease driven by pressure selection and
intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect …

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

The past decade has witnessed a rapid accumulation of evidence showing that hypoxic
microenvironment, which is typical during cancer development, plays key roles in regulating …

To develop new and more efficient anti-cancer strategies it will be important to characterize
the products of transcription factor activity essential for tumorigenesis. One such factor is …

Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …