Macroscopic resting-state brain dynamics are best described by linear models
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
behaviours. Here we challenge this assumption by leveraging mathematical models derived …
Is the brain macroscopically linear? A system identification of resting state dynamics
A central challenge in the computational modeling of neural dynamics is the trade-off
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …
Inferring multi-scale neural mechanisms with brain network modelling
The neurophysiological processes underlying non-invasive brain activity measurements are
incompletely understood. Here, we developed a connectome-based brain network model …
incompletely understood. Here, we developed a connectome-based brain network model …
Inversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain
We considered a large-scale dynamical circuit model of human cerebral cortex with region-
specific microscale properties. The model was inverted using a stochastic optimization …
specific microscale properties. The model was inverted using a stochastic optimization …
Fast transient networks in spontaneous human brain activity
To provide an effective substrate for cognitive processes, functional brain networks should
be able to reorganize and coordinate on a sub-second temporal scale. We used …
be able to reorganize and coordinate on a sub-second temporal scale. We used …
The dynamic brain: from spiking neurons to neural masses and cortical fields
The cortex is a complex system, characterized by its dynamics and architecture, which
underlie many functions such as action, perception, learning, language, and cognition. Its …
underlie many functions such as action, perception, learning, language, and cognition. Its …
The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core
In the human brain, spontaneous activity during resting state consists of rapid transitions
between functional network states over time but the underlying mechanisms are not …
between functional network states over time but the underlying mechanisms are not …
[HTML][HTML] Dynamic recruitment of resting state sub-networks
Resting state networks (RSNs) are of fundamental importance in human systems
neuroscience with evidence suggesting that they are integral to healthy brain function and …
neuroscience with evidence suggesting that they are integral to healthy brain function and …
Task-driven activity reduces the cortical activity space of the brain: experiment and whole-brain modeling
How a stimulus or a task alters the spontaneous dynamics of the brain remains a
fundamental open question in neuroscience. One of the most robust hallmarks of …
fundamental open question in neuroscience. One of the most robust hallmarks of …
Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition
Large-scale brain networks are often described using resting-state functional magnetic
resonance imaging (fMRI). However, the blood oxygenation level-dependent (BOLD) signal …
resonance imaging (fMRI). However, the blood oxygenation level-dependent (BOLD) signal …