Macroscopic resting-state brain dynamics are best described by linear models

E Nozari, MA Bertolero, J Stiso, L Caciagli… - Nature biomedical …, 2024 - nature.com
It is typically assumed that large networks of neurons exhibit a large repertoire of nonlinear
behaviours. Here we challenge this assumption by leveraging mathematical models derived …

Is the brain macroscopically linear? A system identification of resting state dynamics

E Nozari, MA Bertolero, J Stiso, L Caciagli… - arXiv preprint arXiv …, 2020 - arxiv.org
A central challenge in the computational modeling of neural dynamics is the trade-off
between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are …

Inferring multi-scale neural mechanisms with brain network modelling

M Schirner, AR McIntosh, V Jirsa, G Deco, P Ritter - elife, 2018 - elifesciences.org
The neurophysiological processes underlying non-invasive brain activity measurements are
incompletely understood. Here, we developed a connectome-based brain network model …

Inversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain

P Wang, R Kong, X Kong, R Liégeois, C Orban… - Science …, 2019 - science.org
We considered a large-scale dynamical circuit model of human cerebral cortex with region-
specific microscale properties. The model was inverted using a stochastic optimization …

Fast transient networks in spontaneous human brain activity

AP Baker, MJ Brookes, IA Rezek, SM Smith, T Behrens… - elife, 2014 - elifesciences.org
To provide an effective substrate for cognitive processes, functional brain networks should
be able to reorganize and coordinate on a sub-second temporal scale. We used …

The dynamic brain: from spiking neurons to neural masses and cortical fields

G Deco, VK Jirsa, PA Robinson… - PLoS computational …, 2008 - journals.plos.org
The cortex is a complex system, characterized by its dynamics and architecture, which
underlie many functions such as action, perception, learning, language, and cognition. Its …

The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

G Deco, ML Kringelbach, VK Jirsa, P Ritter - Scientific reports, 2017 - nature.com
In the human brain, spontaneous activity during resting state consists of rapid transitions
between functional network states over time but the underlying mechanisms are not …

[HTML][HTML] Dynamic recruitment of resting state sub-networks

GC O'Neill, M Bauer, MW Woolrich, PG Morris… - Neuroimage, 2015 - Elsevier
Resting state networks (RSNs) are of fundamental importance in human systems
neuroscience with evidence suggesting that they are integral to healthy brain function and …

Task-driven activity reduces the cortical activity space of the brain: experiment and whole-brain modeling

A Ponce-Alvarez, BJ He, P Hagmann… - PLoS computational …, 2015 - journals.plos.org
How a stimulus or a task alters the spontaneous dynamics of the brain remains a
fundamental open question in neuroscience. One of the most robust hallmarks of …

Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition

RA Ozdemir, E Tadayon, P Boucher… - Proceedings of the …, 2020 - National Acad Sciences
Large-scale brain networks are often described using resting-state functional magnetic
resonance imaging (fMRI). However, the blood oxygenation level-dependent (BOLD) signal …