Animal models of dementia and cognitive dysfunction

RK Sodhi, AS Jaggi, N Singh - Life Sciences, 2014 - Elsevier
Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease and other cognitive deficits have pointed to novel strategies for drug …

Drug discovery in dementia: the role of rodent models

D Van Dam, PP De Deyn - Nature reviews Drug discovery, 2006 - nature.com
Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease have pointed to novel strategies for drug development. Animal models …

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

K Yamada, T Nabeshima - Pharmacology & therapeutics, 2000 - Elsevier
Alzheimer's disease (AD) is the most common cause of progressive decline of cognitive
function in aged humans, and is characterized by the presence of numerous senile plaques …

The animal models of dementia and Alzheimer's disease for pre-clinical testing and clinical translation

A Anand, A Banik, K Thakur… - Current Alzheimer …, 2012 - ingentaconnect.com
Dementia is a clinical syndrome with abnormal degree of memory loss and impaired ability
to recall events from the past often characterized by Alzheimer's disease. The various …

Animal models of Alzheimer's disease: An origin of innovative treatments and insight to the disease's etiology

RS Chavan, KV Supalkar, SS Sadar, NS Vyawahare - Brain Research, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The main
pathogenic features are the development and deposition of senile plaques and …

Rodent models for Alzheimer's disease drug discovery

D Puzzo, W Gulisano, A Palmeri… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …

Animal models of Alzheimer's disease and drug development

B Laurijssens, F Aujard, A Rahman - Drug Discovery Today: Technologies, 2013 - Elsevier
Animal disease models are considered important in the development of drugs for
Alzheimer's disease. This brief review will discuss possible reasons why their success in …

Animal models of Alzheimer's disease: preclinical insights and challenges

QQ Xu, W Yang, M Zhong, ZX Lin, NE Gray… - Acta Materia …, 2023 - scienceopen.com
Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …

Lower vertebrate and invertebrate models of Alzheimer's disease–A review

N Sharma, N Khurana, A Muthuraman - European journal of pharmacology, 2017 - Elsevier
Alzheimer's disease is a common neurodegenerative disorder which is characterized by the
presence of beta-amyloid protein and neurofibrillary tangles (NFTs) in the brain. Till now …

Alzheimer's disease animal models: elucidation of biomarkers and therapeutic approaches for cognitive impairment

T Nakai, K Yamada, H Mizoguchi - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder. It
is widely accepted that AD is mainly caused by the accumulation of extracellular amyloid β …