Emerging experimental models for assessing perineural invasion in human cancers
SH Jiang, S Zhang, H Wang, JL Xue, ZG Zhang - Cancer Letters, 2022 - Elsevier
Cancer neuroscience has emerged as a burgeoning field for the investigation of cancer-
nervous system interactions. Perineural invasion (PNI) is defined as the presence of cancer …
nervous system interactions. Perineural invasion (PNI) is defined as the presence of cancer …
An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
S Deborde, Y Yu, A Marcadis, CH Chen, N Fan… - JoVE (Journal of …, 2018 - jove.com
Cancer cells invade nerves through a process termed perineural invasion (PNI), in which
cancer cells proliferate and migrate in the nerve microenvironment. This type of invasion is …
cancer cells proliferate and migrate in the nerve microenvironment. This type of invasion is …
The biology and engineered modeling strategies of cancer-nerve crosstalk
A recent finding critical to cancer aggravation is the interaction between cancer cells and
nerves. There exist two main modes of cancer-nerve interaction: perineural invasion (PNI) …
nerves. There exist two main modes of cancer-nerve interaction: perineural invasion (PNI) …
[HTML][HTML] Role of the nervous system in cancers: a review
H Wang, Q Zheng, Z Lu, L Wang, L Ding, L Xia… - Cell death …, 2021 - nature.com
Nerves are important pathological elements of the microenvironment of tumors, including
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …
The chick chorioallantoic membrane in vivo model to assess perineural invasion in head and neck cancer
LB Schmitd, M Liu, CS Scanlon, R Banerjee… - JoVE (Journal of …, 2019 - jove.com
Perineural invasion is a phenotype in which cancer surrounds or invades the nerves. It is
associated with poor clinical outcome for head and neck squamous cell carcinoma and …
associated with poor clinical outcome for head and neck squamous cell carcinoma and …
[HTML][HTML] Unraveling the mysteries of perineural invasion in benign and malignant conditions
HF Bahmad, S Gogola, M Rejzer, K Stoyanov… - Current …, 2023 - mdpi.com
Perineural invasion (PNI) is defined as the dissemination of neoplastic cells within the
perineural space. PNI can be a strong indicator of malignancy and is linked to poor …
perineural space. PNI can be a strong indicator of malignancy and is linked to poor …
Understanding and modeling nerve–cancer interactions
The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …
multiple cancer types have shown that higher intratumoral nerve density is associated with …
Unveiling the pathogenesis of perineural invasion from the perspective of neuroactive molecules
MM da Rosa, MC Sampaio, RVC Santos… - Biochemical …, 2021 - Elsevier
Perineural invasion (PNI) is characterized by an encounter between the cancer cells and
neuronal fibers and holds an extremely poor prognosis for malignant tumors. The exact …
neuronal fibers and holds an extremely poor prognosis for malignant tumors. The exact …
[HTML][HTML] Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche
SH Chen, BY Zhang, B Zhou, CZ Zhu… - American journal of …, 2019 - ncbi.nlm.nih.gov
Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor
metastasis and invasion and portends the poor prognosis of patients. The pathological …
metastasis and invasion and portends the poor prognosis of patients. The pathological …
Mechanisms of cancer dissemination along nerves
The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …