Cancer neuroscience has emerged as a burgeoning field for the investigation of cancer-
nervous system interactions. Perineural invasion (PNI) is defined as the presence of cancer …

Cancer cells invade nerves through a process termed perineural invasion (PNI), in which
cancer cells proliferate and migrate in the nerve microenvironment. This type of invasion is …

A recent finding critical to cancer aggravation is the interaction between cancer cells and
nerves. There exist two main modes of cancer-nerve interaction: perineural invasion (PNI) …

Nerves are important pathological elements of the microenvironment of tumors, including
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …

Perineural invasion is a phenotype in which cancer surrounds or invades the nerves. It is
associated with poor clinical outcome for head and neck squamous cell carcinoma and …

Perineural invasion (PNI) is defined as the dissemination of neoplastic cells within the
perineural space. PNI can be a strong indicator of malignancy and is linked to poor …

The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …

Perineural invasion (PNI) is characterized by an encounter between the cancer cells and
neuronal fibers and holds an extremely poor prognosis for malignant tumors. The exact …

Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor
metastasis and invasion and portends the poor prognosis of patients. The pathological …

The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …