Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the
Mediterranean diet, provide health benefits to humans. Nitric oxide (• NO) and nitrite (NO2−) …

Recent studies in animal systems have shown that NO can interact with fatty acids to
generate nitro-fatty acids (NO 2-FAs). They are the product of the reaction between reactive …

Nitrate fatty acids (NO2-FAs) are considered reactive lipid species derived from the non-
enzymatic oxidation of polyunsaturated fatty acids by nitric oxide (NO) and related species …

The structural modifications of the unsaturated fatty acid components of triglycerides in extra
virgin olive oil (EVOO) following exposure to nitrite ions in acidic media were determined by …

Electrophilic fatty acid nitroalkenes (NO 2-FA) are products of nitric oxide and nitrite-
mediated unsaturated fatty acid nitration. These electrophilic products induce pleiotropic …

Nitrated fatty acids are endogenously present in human and animal tissues, as well as in
plant-derived oils. In particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2 …

Fatty acid nitroalkenes (NO 2-FA) are endogenously-generated products of the reaction of
metabolic and inflammatory-derived nitrogen dioxide (. NO 2) with unsaturated fatty acids …

Unsaturated nitro fatty acids (NO2-FAs) constitute a category of molecules that may be
formed endogenously by the reaction of unsaturated fatty acids (UFAs) with secondary …

Highlights•Formation of nitro-fatty acids.•Signaling of nitro-fatty acids.•Anti-fibrotic effects of
nitro-fatty acids.Fatty acids not only provide caloric energy in our diets and building blocks of …

Cardiovascular disease (CVD) is the leading cause of death and accounts for one third of
disease-related mortality worldwide. Dysregulated redox mechanisms, in particular the …