Physiologically based pharmacokinetic (PBPK) models are useful in bridging drug exposure
in different ethnic groups, and there is increasing regulatory application of this approach in …

The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children,
especially those younger than 2 years old, has not been systematically evaluated. The aim …

The accurate prediction of pharmacokinetics (PK) is fundamental to underwriting safety and
efficacy in pediatric clinical trials; age‐dependent PK may be observed with pediatrics …

Robust prediction of pharmacokinetics (PKs) in pediatric subjects of diverse ages,
ethnicities, and morbidities is critical. Qualification of pediatric physiologically‐based …

Physiologically based pharmacokinetic (PBPK) approaches that incorporate the
developmental physiology and ontogeny of cytochrome P450 (CYP) enzymes may have …

Physiologically based pharmacokinetic (PBPK) models offer a mechanistic understanding of
the disposition of the drug in the body. When well informed and conducted, this may lead to …

Background: Physiologically based pharmacokinetic (PBPK) modeling and simulating may
be a powerful tool in predicting drug behaviors in specific populations. It is a mathematical …

The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK)
models, particularly for regulatory applications, has focused emphasis on model verification …

Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the estimation of
pharmacokinetic (PK) parameters in children under specific exposure conditions. In human …

This mini-review examines the current state of pediatric physiologically-based
pharmacokinetic (PBPK) modeling, including methodologies, approaches, and recent …