The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

B Bottazzi, A Inforzato, M Messa, M Barbagallo… - Journal of …, 2016 - Elsevier
Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …

Pentraxins in innate immunity: lessons from PTX3

L Deban, S Jaillon, C Garlanda, B Bottazzi… - Cell and tissue …, 2011 - Springer
The innate immune system constitutes the first line of defence against microorganisms and
plays a primordial role in the activation and regulation of adaptive immunity. The innate …

The long pentraxin PTX3 in vascular pathology

A Mantovani, C Garlanda, B Bottazzi, G Peri… - Vascular …, 2006 - Elsevier
Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition
proteins characterized by a cyclic multimeric structure. Based on the primary structure of the …

Pentraxins: multifunctional proteins at the interface of innate immunity and inflammation

L Deban, B Bottazzi, C Garlanda, YM de la Torre… - Biofactors, 2009 - Wiley Online Library
Pentraxins are a family of multimeric pattern recognition proteins highly conserved in
evolution. On the basis of the primary structure of the protomer, pentraxins are divided into …

Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3

A Mantovani, C Garlanda, A Doni, B Bottazzi - Journal of clinical …, 2008 - Springer
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in
evolution. Based on the primary structure of the subunit, the pentraxins are divided into two …

The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling

A Inforzato, S Jaillon, F Moalli, E Barbati… - Tissue …, 2011 - Wiley Online Library
Innate immunity represents the first line of defence against pathogens and plays key roles in
the activation and orientation of the adaptive immune response. The innate immune system …

The dual complexity of PTX3 in health and disease: a balancing act?

E Magrini, A Mantovani, C Garlanda - Trends in molecular medicine, 2016 - cell.com
The humoral arm of innate immunity is complex and includes various molecules that serve
as markers of inflammation with complementary characteristics, such as the short pentraxins …

Pentraxins and atherosclerosis: the role of PTX3

C Garlanda, B Bottazzi, F Moalli… - Current …, 2011 - ingentaconnect.com
Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition
proteins characterized by a cyclic multimeric structure. Based on the primary structure of the …

[HTML][HTML] Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role

H Zhang, R Wang, Z Wang, W Wu, N Zhang… - Biomedicine & …, 2022 - Elsevier
Abstract Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …

The long pentraxin PTX3 as a link between innate immunity, tissue remodeling, and cancer

A Doni, M Stravalaci, A Inforzato, E Magrini… - Frontiers in …, 2019 - frontiersin.org
The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …