Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: Molecular docking and molecular dynamics …

K Chaieb, B Kouidhi, SB Hosawi… - Computers in Biology …, 2022 - Elsevier
Quorum sensing (QS) is a bacterial communication strategy controlling cells density, biofilm
formation, virulence, sporulation, and survival. Since QS is considered a virulence factor in …

Functional diversity of quorum sensing receptors in pathogenic bacteria: Interspecies, intraspecies and interkingdom level

F Khan, A Javaid, YM Kim - Current drug targets, 2019 - ingentaconnect.com
The formation of biofilm by pathogenic bacteria is considered as one of the most powerful
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …

Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database

SYY Tan, SL Chua, Y Chen, SA Rice… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Bacteria communicate by means of small signal molecules in a process termed quorum
sensing (QS). QS enables bacteria to organize their activities at the population level …

Energy-optimized pharmacophore coupled virtual screening in the discovery of quorum sensing inhibitors of LasR protein of Pseudomonas aeruginosa

Z Nain, SB Sayed, MM Karim, MA Islam… - Journal of …, 2020 - Taylor & Francis
Pseudomonas aeruginosa is an emerging opportunistic pathogen responsible for cystic
fibrosis and nosocomial infections. In addition, empirical treatments are become inefficient …

Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions

L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …

Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa

F D'Angelo, V Baldelli, N Halliday… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A
promising strategy to combat bacterial infections aims at hampering their adaptability to the …

Natural quorum sensing inhibitors–small molecules, big messages

A Delago, A Mandabi, MM Meijler - Israel Journal of Chemistry, 2016 - Wiley Online Library
Due to the increasing emergence of antibiotic resistant bacterial strains within the past few
decades, bacterial infections in general–and hospital‐borne infections, in particular–have …

Inhibition of Quorum-Sensing Regulator from Pseudomonas aeruginosa Using a Flavone Derivative

Y Xie, J Chen, B Wang, AY Peng, ZW Mao, W Xia - Molecules, 2022 - mdpi.com
Quorum sensing (QS) is a cell-to-cell communication process that controls bacterial
collective behaviors. The QS network regulates and coordinates bacterial virulence factor …

Investigation of Pseudomonas aeruginosa quorum-sensing signaling system for identifying multiple inhibitors using molecular docking and structural analysis …

V Soheili, BSF Bazzaz, N Abdollahpour… - Microbial …, 2015 - Elsevier
Pseudomonas aeruginosa is an opportunistic human pathogen and a common Gram-
negative bacterium in hospital-acquired infections. It causes death in many burn victims …

Investigation of Direct and Retro Chromone-2-Carboxamides Based Analogs of Pseudomonas aeruginosa Quorum Sensing Signal as New Anti-Biofilm Agents

J Trognon, G Vera, M Rima, JL Stigliani, L Amielet… - Pharmaceuticals, 2022 - mdpi.com
Biofilm formation is considered a major cause of therapeutic failure because bacteria in
biofilms have higher protection against antimicrobials. Thus, biofilm-related infections are …