Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: Molecular docking and molecular dynamics …
Quorum sensing (QS) is a bacterial communication strategy controlling cells density, biofilm
formation, virulence, sporulation, and survival. Since QS is considered a virulence factor in …
formation, virulence, sporulation, and survival. Since QS is considered a virulence factor in …
Functional diversity of quorum sensing receptors in pathogenic bacteria: Interspecies, intraspecies and interkingdom level
The formation of biofilm by pathogenic bacteria is considered as one of the most powerful
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …
Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database
Bacteria communicate by means of small signal molecules in a process termed quorum
sensing (QS). QS enables bacteria to organize their activities at the population level …
sensing (QS). QS enables bacteria to organize their activities at the population level …
Energy-optimized pharmacophore coupled virtual screening in the discovery of quorum sensing inhibitors of LasR protein of Pseudomonas aeruginosa
Pseudomonas aeruginosa is an emerging opportunistic pathogen responsible for cystic
fibrosis and nosocomial infections. In addition, empirical treatments are become inefficient …
fibrosis and nosocomial infections. In addition, empirical treatments are become inefficient …
Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions
L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …
Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa
F D'Angelo, V Baldelli, N Halliday… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A
promising strategy to combat bacterial infections aims at hampering their adaptability to the …
promising strategy to combat bacterial infections aims at hampering their adaptability to the …
Natural quorum sensing inhibitors–small molecules, big messages
A Delago, A Mandabi, MM Meijler - Israel Journal of Chemistry, 2016 - Wiley Online Library
Due to the increasing emergence of antibiotic resistant bacterial strains within the past few
decades, bacterial infections in general–and hospital‐borne infections, in particular–have …
decades, bacterial infections in general–and hospital‐borne infections, in particular–have …
Inhibition of Quorum-Sensing Regulator from Pseudomonas aeruginosa Using a Flavone Derivative
Quorum sensing (QS) is a cell-to-cell communication process that controls bacterial
collective behaviors. The QS network regulates and coordinates bacterial virulence factor …
collective behaviors. The QS network regulates and coordinates bacterial virulence factor …
Investigation of Pseudomonas aeruginosa quorum-sensing signaling system for identifying multiple inhibitors using molecular docking and structural analysis …
V Soheili, BSF Bazzaz, N Abdollahpour… - Microbial …, 2015 - Elsevier
Pseudomonas aeruginosa is an opportunistic human pathogen and a common Gram-
negative bacterium in hospital-acquired infections. It causes death in many burn victims …
negative bacterium in hospital-acquired infections. It causes death in many burn victims …
Investigation of Direct and Retro Chromone-2-Carboxamides Based Analogs of Pseudomonas aeruginosa Quorum Sensing Signal as New Anti-Biofilm Agents
J Trognon, G Vera, M Rima, JL Stigliani, L Amielet… - Pharmaceuticals, 2022 - mdpi.com
Biofilm formation is considered a major cause of therapeutic failure because bacteria in
biofilms have higher protection against antimicrobials. Thus, biofilm-related infections are …
biofilms have higher protection against antimicrobials. Thus, biofilm-related infections are …
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