Basic research and clinical studies have implicated a role for hyperuricemia and for xanthine
oxidoreductase (XOR), the enzyme that generates uric acid (UA), in not only gout but also …

Epidemiological and experimental studies have shown that hyperuricaemia and gout are
independent risk factors for cardiovascular diseases. The mechanisms that link high serum …

Gout, a chronic rheumatologic illness characterized by hyperuricemia, arthri-tis, tophaceous
deposits, and renal calculi, is associated with increased rates of cardiovascular and chronic …

Uric acid has been long recognized as the cause of gouty arthritis and kidney stones. There
is mounting evidence that it may also have an important role in the development of vascular …

Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …

For many years, the relationship between cardiovascular disease risk and gout, though
strong and consistent, was suspected of being coincidental rather than causative. In recent …

Borghi and Desideri Allopurinol and Cardiovascular Disease 497 the increase in the
endothelium-dependent forearm vasodilatation was enhanced by allopurinol in a dose …

Background Hyperuricemia and gout are associated with an increased risk of cardiovascular
disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase …

Epidemiological and experimental studies have shown that hyperuricaemia and gout are
intricately linked with hypertension, metabolic syndrome, chronic kidney disease and …

Uric acid was first associated with primary hypertension in 1874, yet its role in this condition
remains unclear. Historically, uric acid was thought to be a secondary response to …