Comparative analysis of Radachlorin accumulation, localization, and photobleaching in three cell lines by means of holographic and fluorescence microscopy

AA Zhikhoreva, AV Belashov, TN Belyaeva… - Photodiagnosis and …, 2022 - Elsevier
In this paper we compare the response of cells of established lines of different origin: HeLa,
A549 and 3T3 to photodynamic treatment with Radachlorin photosensitizer. The analysis …

[HTML][HTML] Analysis of Radachlorin localization in living cells by fluorescence lifetime imaging microscopy

AV Belashov, AA Zhikhoreva, AV Salova… - … of Photochemistry and …, 2023 - Elsevier
Intracellular localization of photosensitizer molecules is influential on cell death pathway at
photodynamic treatment and is thus an important aspect in achieving enhanced efficacy of …

Necrosis and apoptosis pathways of cell death at photodynamic treatment in vitro as revealed by digital holographic microscopy

IV Semenova, AV Belashov… - … , and Analysis of …, 2018 - spiedigitallibrary.org
Monitoring of variations in morphological characteristics of cultured HeLa cells after
photodynamic treatment with Radachlorin photosensitizer is performed by means of digital …

Analysis of In Vivo Radachlorin Accumulation through FLIM-Assisted Examination of Ex Vivo Histological Samples

AV Belashov, AA Zhikhoreva, SS Kruglov… - Photonics, 2022 - mdpi.com
We report an investigation of the in vivo accumulation of Radachlorin photosensitizer in a
murine model in several types of normal and tumor tissues based on an FLIM-assisted …

[HTML][HTML] In vitro evaluation of Radachlorin® sensitizer for photodynamic therapy

S Douillard, I Lhommeau, D Olivier, T Patrice - Journal of Photochemistry …, 2010 - Elsevier
This paper reports the evaluation of a new photosensitizer, Radachlorin® in comparison
with one of its well known components but used solely, Chlorin e6. The photodynamic …

Quantitative assessment of changes in cellular morphology at photodynamic treatment in vitro by means of digital holographic microscopy

AV Belashov, AA Zhikhoreva, TN Belyaeva… - Biomedical optics …, 2019 - opg.optica.org
Temporal dependence of changes in the morphological characteristics of cells of two
cultured lines of cancer origin, HeLa and A549, induced by photodynamic treatment with …

Chlorin e6 derivative radachlorin mainly accumulates in mitochondria, lysosome and endoplasmic reticulum and shows high affinity toward tumors in nude mice in …

R Biswas, JH Moon, JC Ahn - Photochemistry and …, 2014 - Wiley Online Library
The efficacy of photodynamic therapy (PDT) depends upon the amount of photosensitizer
accumulated in the malignant tissues. Radachlorin is a popular photosensitizer used in …

Photodynamic effect of Radachlorin on nerve and glial cells

MA Neginskaya, EV Berezhnaya, MV Rudkovskii… - Photodiagnosis and …, 2014 - Elsevier
Background Radachlorin, a chlorine-derived photosensitizer, is used currently in
photodynamic therapy (PDT) of skin cancer. In this work we studied Radachlorin-PDT effect …

In vitro and in vivo evaluation of Radachlorin® sensitizer for photodynamic therapy

S Douillard, D Olivier, T Patrice - Photochemical & Photobiological …, 2009 - Springer
This paper reports the evaluation of a new photosensitizer, Radachlorin® in comparison
with one of its well known components but used solely, Chlorin e6. The photodynamic …

[HTML][HTML] The efficacy of Radachlorin-mediated photodynamic therapy in human hepatocellular carcinoma cells

H Mirzaei, GE Djavid, M Hadizadeh… - … of Photochemistry and …, 2015 - Elsevier
Background Photodynamic therapy (PDT) is a relatively novel modality for the treatment of
cancer and some non-malignant lesions. PDT uses a photosensitive drug and light to …