The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …

Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12–and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …

As anyone who has attended tuberculosis research meeting in recent years can attest,
disputes about validity of experimental animal models of tuberculosis (TB) erupt frequently …

The human genetic basis of tuberculosis (TB) has long remained elusive. We recently
reported a high level of enrichment in homozygosity for the common TYK2 P1104A variant in …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Abstract Vol. 2 Short description Written by prolific specialists in the field, this second volume
of the first comprehensive series on tuberculosis focuses on immunology and cell biology of …

Tuberculosis (TB) is characterized by lifetime persistence of Mycobacterium tuberculosis.
Despite the induction of a vigorous host immune response that curtails disease progression …

Mendelian defects in interferon-γ (IFN-γ) signaling most commonly lead to infection with
nontuberculous mycobacteria. Mutations have been identified in the genes encoding IFN-γ …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …