Neurodegenerative diseases, including Alzheimer disease, Parkinson disease, amyotrophic
lateral sclerosis, and multiple sclerosis, are chronic disorders of the CNS that are …

Protein tyrosine phosphatases (PTPs) are important regulator of neuronal signal
transduction and a growing number of PTPs have been implicated in Alzheimer's disease …

The modification of proteins by reversible phosphorylation is a key mechanism in the
regulation of various physiological functions. Abnormal protein kinase or phosphatase …

The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the
dephosphorylation of phosphotyrosines in protein molecules. They are involved in cellular …

62 Hunter T: Tyrosine phosphorylation in signaling and disease kinases and 90 tyrosine
kinases. And among the 90 tyrosine kinases, 58 are receptor tyrosine kinases and 32 are …

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated
manner with protein tyrosine kinases to control signalling pathways that underlie a broad …

Disturbance of the dynamic balance between protein tyrosine phosphorylation and
dephosphorylation, modulated by protein tyrosine kinases (PTKs) and protein tyrosine …

Phosphorylated tyrosyl residues in proteins are quantitatively much less abundant in normal
cells than phosphoserines or phosphothreonines, yet tyrosine phosphorylation plays a …

A role for the receptor-like protein tyrosine phosphatase α (PTPα) in regulating the kinase
activity of Src family members has been proposed because ectopic expression of PTPα …

Neuronal cytoskeletal proteins such as neurofilaments (NFs) and tau are aberrantly and
hyperphosphorylated in neurodegeneration. Under normal physiological conditions, NFs …