Salivarian trypanosomosis: a review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune system

M Radwanska, N Vereecke, V Deleeuw… - Frontiers in …, 2018 - frontiersin.org
Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune …

S Magez, JE Pinto Torres, E Obishakin… - Frontiers in …, 2020 - frontiersin.org
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game
animals around the world. Through co-evolution with the mammalian immune system …

Escaping deleterious immune response in their hosts: lessons from trypanosomatids

A Geiger, G Bossard, D Sereno, J Pissarra… - Frontiers in …, 2016 - frontiersin.org
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

African trypanosomes undermine humoral responses and vaccine development: link with inflammatory responses?

B Stijlemans, M Radwanska, C De Trez… - Frontiers in …, 2017 - frontiersin.org
African trypanosomosis is a debilitating disease of great medical and socioeconomical
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …

Trypanosoma brucei triggers a marked immune response in male reproductive organs

T Carvalho, S Trindade, S Pimenta… - PLoS neglected …, 2018 - journals.plos.org
African trypanosomiasis is caused by the protozoan parasite Trypanosoma brucei,
transmitted between mammals by the bite of a tsetse. It has been recently shown that …

Insights into the trypanosome-host interactions revealed through transcriptomic analysis of parasitized tsetse fly salivary glands

EL Telleria, JB Benoit, X Zhao, AF Savage… - PLoS neglected …, 2014 - journals.plos.org
The agents of sleeping sickness disease, Trypanosoma brucei complex parasites, are
transmitted to mammalian hosts through the bite of an infected tsetse. Information on tsetse …

African trypanosomiasis-associated anemia: the contribution of the interplay between parasites and the mononuclear phagocyte system

B Stijlemans, P De Baetselier, S Magez… - Frontiers in …, 2018 - frontiersin.org
African trypanosomosis (AT) is a chronically debilitating parasitic disease of medical and
economic importance for the development of sub-Saharan Africa. The trypanosomes that …

An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction

A Ponte-Sucre - Frontiers in microbiology, 2016 - frontiersin.org
Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human
African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite …