The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …

Replicating the naturalistic biomechanical milieu of cells is a primary requisite to uncover the
fundamental life processes. The native milieu is significantly not replicated in the two …

Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical
models. There is a growing realization that the tumor microenvironment is a critical …

Abstract Three-dimensional (3D) cell cultures have recently garnered great attention
because they promote levels of cells differentiation and tissue organisation not possible in …

Basic in vitro systems can be used to model and assess complex diseases, such as cancer.
Recent advances in this field include the incorporation of multiple cell types and …