Nitroalkene fatty acid derivatives manifest a strong electrophilic nature, are clinically
detectable, and induce multiple transcriptionally regulated anti-inflammatory responses. At …

Abstract Nitro-fatty acids (NO 2-FA) undergo reversible Michael adduction reactions with
cysteine and histidine residues leading to the post-translational modification (PTM) of …

Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-
inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease …

Electrophilic fatty acid nitroalkenes (NO 2-FA) are products of nitric oxide and nitrite-
mediated unsaturated fatty acid nitration. These electrophilic products induce pleiotropic …

Nitric oxide (. NO)-derived reactive species nitrate unsaturated fatty acids, yielding
nitroalkene derivatives, including the clinically abundant nitrated oleic and linoleic acids …

Foundational advances in eicosanoid signaling, the free radical biology of oxygen and nitric
oxide and mass spectrometry all converged to enable the discovery of nitrated unsaturated …

Nitrated derivatives of fatty acids (NO 2-FA) are pluripotent cell-signaling mediators that
display anti-inflammatory properties. Current understanding of NO 2-FA signal transduction …

Nitroalkene fatty acids are formed in vivo and exert protective and anti-inflammatory effects
via reversible Michael addition to thiol-containing proteins in key signaling pathways. Nitro …

Abstract Nitro-fatty acids (NO 2-FA) are metabolic and inflammatory-derived electrophiles
that mediate pleiotropic signaling actions. It was hypothesized that NO 2-FA would impact …

A gap in our understanding of the beneficial systemic responses to dietary constituents
nitrate (NO 3−), nitrite (NO 2−) and conjugated linoleic acid (cLA) is the identification of the …