Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1
gene, which encodes fibrillin-1, a protein essential for the formation and stabilization of …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1
(Fbn1). Although aortic rupture is the major cause of mortality in MFS, patients also …

Aims Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the
Fibrillin-1 gene. It is associated with formation of thoracic aortic aneurysms that can …

Background and purpose: Aortic complications account for the major mortality in Marfan
syndrome (MFS), a connective tissue disorder caused by mutations in FBN1 encoding …

Marfan syndrome (MFS) is a genetic disorder that affects multiple organs. Mortality imposed
by aortic aneurysm and dissections represent the most serious clinical manifestation of MFS …

Background The major clinical problem of Marfan syndrome (MFS) is the aortic root
aneurysm, with risk of dissection when the root diameter approximates 5 cm. In MFS, a key …

Marfan syndrome (MS) is of the most common connective tissue disorders. Although most
patients have mutations in the fibrillin-1 gene (FBN1) and more than 1,700 mutations have …

Marfan syndrome (MFS) is a connective tissue disorder that is often associated with the
fibrillin-1 (Fbn1) gene mutation and characterized by cardiovascular alterations …

The Marfan syndrome (MFS) is a systemic connective tissue disorder caused by mutations in
the FBN1 gene. Recent molecular studies, most performed in mouse models, revealed that …

Marfan syndrome (MFS) is an inherited autosomal dominant multisystem disease caused by
mutations in the FBN1 gene encoding fibrillin-1, an extracellular matrix glycoprotein widely …