Down-regulation of the initial burst of viremia during primary HIV infection is thought to be
mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this …

Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells in early infection are
associated with the dramatic decline of peak viremia, whereas their antiviral activity in …

Multiple lines of evidence support a role for CD8+ T cells in control of acute/early HIV
replication; however, features of the primary HIV-specific CD8+ T cell response that may …

In chronic viral infections of humans and experimental animals, virus-specific CD4+ T cell
function is believed to be critical for induction and maintenance of host immunity that …

Virus-specific CD8+ T cells are associated with declining viremia in acute human
immunodeficiency virus (HIV) 1 infection, but do not correlate with control of viremia in …

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV)
infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in …

Attrition within the CD4+ T cell compartment, high viremia, and a cytokine storm characterize
the early days after HIV infection. When the first emerging HIV-specific CD8+ T cell …

Impairment of CD4+ T lymphocyte responses to human immunodeficiency virus (HIV)‐
derived antigens is the classic immunological defect observed during the chronic phase of …

Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T
lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells …

CD8+ T cells are critical for effective host defenses against viral infections. Studies
addressing HIV-induced immune responses in infected individuals have suggested that …