[HTML][HTML] Some pyrimidohexahydroquinoline candidates: synthesis, DFT, cytotoxic activity evaluation, molecular docking, and in silico studies
SK Ramadan, HSM Abd-Rabboh, AAA Hafez… - RSC …, 2024 - pubs.rsc.org
Some hexahydroquinoline candidates were prepared by reacting 2-amino-3-cyano-1-
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
[HTML][HTML] Quinoline-pyrimidine hybrid compounds from 3-acetyl-4-hydroxy-1-methylquinolin-2 (1H)-one: Study on synthesis, cytotoxicity, ADMET and molecular docking
Abstract Some novel 2-amino-6-aryl-4-(4′-hydroxy-N-methylquinolin-2′-on-3′-yl)
pyrimidines have been synthesized from α, β-unsaturated ketones of 3-acetyl-4-hydroxy-N …
pyrimidines have been synthesized from α, β-unsaturated ketones of 3-acetyl-4-hydroxy-N …
Novel quinoxaline derivatives of 2, 3-diphenylquinoxaline-6-carbaldehyde and 4, 4′-(6-methylquinoxaline-2, 3-diyl) bis (N, N-diphenylaniline): Synthesis, structural …
JI Ahamed, GR Ramkumaar, P Kamalarajan… - Journal of Molecular …, 2022 - Elsevier
Abstract The quinoxaline derivatives of 2, 3-diphenylquinoxaline-6-carbaldehyde (DPQC)
and 4, 4′-(6-methylquinoxaline-2, 3-diyl) bis (N, N-diphenylaniline)(MDBD) were …
and 4, 4′-(6-methylquinoxaline-2, 3-diyl) bis (N, N-diphenylaniline)(MDBD) were …
Synthesis, anti-proliferative activity, DFT and docking studies of some novel chloroquinoline-based heterocycles
MF Ismail, A Aboelnaga, MM Naguib… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Cancer is one of the leading causes of death. Quinoline is well known as one of the most
potent pharmaceutically active scaffolds with remarkable pharmacological properties. So, in …
potent pharmaceutically active scaffolds with remarkable pharmacological properties. So, in …
Synthesis and biological studies of oxoquinolines: Experimental and theoretical investigations
The incorporation of quinolines into drugs is critical for accomplishing important tasks and
acting as an active ingredient in a variety of treatments. In the present investigation, N-aryl-7 …
acting as an active ingredient in a variety of treatments. In the present investigation, N-aryl-7 …
2-(Chloromethyl)-3-phenylquinazolin-4 (3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies
In order to show antiproliferation and cancerous cell growth inhibition of quinazoline
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …
[HTML][HTML] Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents
A series of quinazolinone derivatives (7a–7h) were synthesized as antiproliferative agents.
All compounds, were synthesized through three steps method and structurally evaluated by …
All compounds, were synthesized through three steps method and structurally evaluated by …
[HTML][HTML] Design, synthesis, in vitro antiproliferative effect and in situ molecular docking studies of a series of new benzoquinoline derivatives
Quinoline derivatives have been reported to possess multi-therapeutic potential owing to the
manifestations of different pharmacological effects. The current research work describes …
manifestations of different pharmacological effects. The current research work describes …
[HTML][HTML] Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl) …
S Mehta, S Kumar, RK Marwaha, B Narasimhan… - BMC chemistry, 2019 - Springer
In the present study, a series of 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-
oxoquinazolin-3 (4 H)-yl) acetamide derivatives was synthesized and its chemical structures …
oxoquinazolin-3 (4 H)-yl) acetamide derivatives was synthesized and its chemical structures …
[HTML][HTML] Synthesis and in silico studies of certain benzo[f]quinoline-based heterocycles as antitumor agents
A series of benzoquinoline-employing heterocycles was synthesized by treating 3-
chlorobenzo [f] quinoline-2-carbaldehyde with N-phenyl-3-methylpyrazolone, 4 …
chlorobenzo [f] quinoline-2-carbaldehyde with N-phenyl-3-methylpyrazolone, 4 …