A topic of high current interest and controversy is the basis of the homeostatic sleep
response, the increase in non-rapid-eye-movement (NREM) sleep and NREM-delta activity …

It is currently hypothesized that the drive to sleep is determined by the activity of the basal
forebrain (BF) cholinergic neurons, which release adenosine (AD), perhaps because of …

Adenosine has been proposed as an endogenous homeostatic sleep factor that
accumulates during waking and inhibits wake-active neurons to promote sleep. It has been …

This review describes a series of animal experiments that investigate the role of
endogenous adenosine (AD) in sleep. We propose that AD is a modulator of the sleepiness …

Adenosine has been proposed as a homeostatic “sleep factor” that promotes the transition
from waking to sleep by affecting several sleep–wake regulatory systems. In the basal …

Recent research has shown that neurons in the ventrolateral preoptic nucleus are crucial for
sleep by inhibiting wake-promoting systems, but the process that triggers their activation at …

Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular
adenosine concentrations increase during wakefulness, especially during prolonged …

A prolonged period of waking accumulates sleep pressure, increasing both the duration and
the intensity of the subsequent sleep period. Delta power, which is calculated from the slow …

Alcohol has a profound effect on sleep. However, neuronal substrates mediating sleep‐
promoting effects of alcohol are unknown. Since the basal forebrain (BF) cholinergic …

Adenosine is directly linked to the energy metabolism of cells. In the central nervous system
(CNS) an increase in neuronal activity enhances energy consumption as well as …