Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a
pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) …

Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a
pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) …

Rare mutations in TARDBP, the gene encoding TDP-43, cause amyotrophic lateral sclerosis
(ALS), and TDP-43 pathology is seen in a large majority of ALS patients, suggesting a …

Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating
disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology …

TDP-43 aggregates are the defining pathological hallmark for amyotrophic lateral sclerosis
(ALS) and frontotemporal dementia (FTD). Strikingly, these TDP-43 proteinopathies are also …

Introduction Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive
neurodegenerative disorder, and cytoplasmic inclusions containing transactive response …

Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper-and lower motor
neurons. Post-mortem, nearly all ALS cases are positive for cytoplasmic aggregates …

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor
neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing and fatal disease characterized
by muscular atrophy because of loss of upper and lower motor neurons. Histopathologically …

Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease that
affects∼ 2/100 000 individuals each year worldwide. Patients with ALS suffer from rapidly …