Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Introduction• Overview of signalling pathways involved in disuse‐induced muscle atrophy‐
Changes in protein synthesis and associated signalling pathways‐Several pathways …

Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Prolonged unloading of skeletal muscle, a common outcome of events such as spaceflight,
bed rest and hindlimb unloading, can result in extensive metabolic, structural and functional …

Skeletal muscle atrophy occurs as a consequence of injury, illness, surgery, and muscle
disuse, impacting appreciably on health care costs and patient quality of life, particularly in …

Muscle wasting resulting wholly or in part from disuse represents a serious medical
complication that, when prolonged, can increase morbidity and mortality. Although much …

Prolonged periods of skeletal muscle inactivity due to bed rest, denervation, hindlimb
unloading, immobilization, or microgravity can result in significant muscle atrophy. The …

Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-
generating capacity. This disuse-induced muscle atrophy results from both increased …

Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional
consequences. While the initiating physiological event leading to atrophy seems to be the …