PURPOSE Neoadjuvant chemotherapy (NAC) has potential advantages over standard
postoperative chemotherapy for locally advanced colon cancer but requires formal …

Background NAC has an established role in many solid tumours but its utility has not
previously been formally evaluated in colon cancer. Methods Pts with CT-staged T3-4 N0-2 …

Background Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective
than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps …

Background The role of perioperative or neoadjuvant chemotherapy for locally advanced
colon cancer is unclear. Emerging evidence such as the FOXTROT trial is challenging the …

3504 Background: NAC is well established in many solid tumours but has not undergone
large-scale evaluation in colon cancer. Methods: Pts had operable, non-obstructed colon …

Background. Neoadjuvant chemotherapy has proven valuable in several tumors, but it has
not been elucidated in colon cancer. The present phase II trial addressed the issue in high …

Background There is increasing evidence to support the use of neoadjuvant chemotherapy
(NAC) in locally advanced colon cancer (LACC). However, its safety, efficacy and side effect …

Neoadjuvant systemic therapy has many potential advantages over up-front surgery,
including tumor downstaging, early treatment of micrometastatic disease, and providing an …

Purpose Neoadjuvant chemotherapy is being actively tested as an emerging alternative for
the treatment of locally advanced colon cancer (LACC) patients, resembling its use in other …

The adjuvant treatment of patients with stage II colon cancer is an area of controversy in
medical oncology. Adjuvant chemotherapy aims to eradicate micrometastatic disease …