[HTML][HTML] GPR35 acts a dual role and therapeutic target in inflammation

Y Wu, P Zhang, H Fan, C Zhang, P Yu, X Liang… - Frontiers in …, 2023 - frontiersin.org
GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory
responses. Although the precise role of GPR35 in inflammation is not yet fully understood …

[HTML][HTML] G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

N Divorty, AE Mackenzie, SA Nicklin… - Frontiers in …, 2015 - frontiersin.org
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has
garnered interest as a potential therapeutic target through its association with a range of …

[HTML][HTML] GPR41 and GPR43 in obesity and inflammation–protective or causative?

Z Ang, JL Ding - Frontiers in immunology, 2016 - frontiersin.org
GPR41 and GPR43 are a pair of mammalian G protein-coupled receptors (GPCRs)
expressed in human adipocytes, colon epithelial cells, and peripheral blood mononuclear …

From orphan to oncogene: The role of GPR35 in cancer and immune modulation

S Takkar, G Sharma, JB Kaushal, KM Abdullah… - Cytokine & Growth …, 2024 - Elsevier
G protein-coupled receptors (GPCRs) are well-studied and the most traceable cell surface
receptors for drug discovery. One of the intriguing members of this family is G protein …

[HTML][HTML] G protein–coupled receptor 21 in macrophages: An in vitro study

V Bordano, GK Kinsella, S Cannito, C Dianzani… - European Journal of …, 2022 - Elsevier
GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-
Protein Coupled Receptors (GPCRs). GPR21 couples to the G q family of G proteins and is …

[HTML][HTML] Activation of the immune-metabolic receptor GPR84 enhances inflammation and phagocytosis in macrophages

C Recio, D Lucy, GSD Purvis, P Iveson… - Frontiers in …, 2018 - frontiersin.org
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression
has been described predominantly in immune cells. GPR84 activation is involved in the …

[HTML][HTML] Novel GPR43 agonists exert an anti-inflammatory effect in a colitis model

BO Park, JS Kang, S Paudel, SG Park… - Biomolecules & …, 2022 - ncbi.nlm.nih.gov
GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated
by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism …

[PDF][PDF] GPR84: an immune response dial?

ML Wojciechowicz, A Ma'ayan - Nature reviews. Drug discovery, 2020 - drive.google.com
GPR84 is an understudied Gi-coupled G-protein-coupled receptor (GPCR) that is expressed
on the surface of immune cells. Recently, the synthesis and discovery of chemical agonists …

[HTML][HTML] Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health …

E Honkisz-Orzechowska, D Łażewska, G Baran… - Molecules, 2024 - mdpi.com
The resolution of inflammation is the primary domain of specialised pro-resolving mediators
(SPMs), which include resolvins, protectins, and their forms synthesised under the influence …

Discovery of nitrophenols as GPR35 agonists

H Deng, Y Fang - MedChemComm, 2012 - pubs.rsc.org
GPR35 is a family A orphan G protein-coupled receptor whose biological functions are
largely unknown. Identification of novel GPR35 ligands is essential to elucidate the biology …