Biodegradable polyurethane ureas with variable polyester or polycarbonate soft segments: Effects of crystallinity, molecular weight, and composition on mechanical …

Z Ma, Y Hong, DM Nelson, JE Pichamuthu… - …, 2011 - ACS Publications
Biodegradable polyurethane urea (PUU) elastomers are ideal candidates for fabricating
tissue engineering scaffolds with mechanical properties akin to strong and resilient soft …

Low-initial-modulus biodegradable polyurethane elastomers for soft tissue regeneration

C Xu, Y Huang, L Tang, Y Hong - ACS applied materials & …, 2017 - ACS Publications
The mechanical match between synthetic scaffold and host tissue remains challenging in
tissue regeneration. The elastic soft tissues exhibit low initial moduli with a J-shaped tensile …

Synthesis and characterization of plug-and-play polyurethane urea elastomers as biodegradable matrixes for tissue engineering applications

AP Kishan, T Wilems, S Mohiuddin… - ACS Biomaterials …, 2017 - ACS Publications
The highly tunable mechanical properties and resilience of polyurethanes make them
promising candidates for tissue engineering applications. Biodegradability is conferred by …

Tailoring the degradation kinetics of poly (ester carbonate urethane) urea thermoplastic elastomers for tissue engineering scaffolds

Y Hong, J Guan, KL Fujimoto, R Hashizume… - Biomaterials, 2010 - Elsevier
Biodegradable elastomeric scaffolds are of increasing interest for applications in soft tissue
repair and regeneration, particularly in mechanically active settings. The rate at which such …

Elastomeric biodegradable polyurethane blends for soft tissue applications

JD Fromstein, KA Woodhouse - Journal of Biomaterials Science …, 2002 - Taylor & Francis
Four biodegradable polyurethane blends were made from segmented polyurethanes that
contain amino acid-based chain extender and diisocyanate groups. The soft segments of …

Synthesis and characterization of segmented poly (esterurethane urea) elastomers for bone tissue engineering

KD Kavlock, TW Pechar, JO Hollinger, SA Guelcher… - Acta biomaterialia, 2007 - Elsevier
Segmented polyurethanes have been used extensively in implantable medical devices, but
their tunable mechanical properties make them attractive for examining the effect of …

[PDF][PDF] Biodegradable synthetic polymers for tissue engineering

PA Gunatillake, R Adhikari, N Gadegaard - Eur Cell Mater, 2003 - scirp.org
This paper reviews biodegradable synthetic polymers focusing on their potential in tissue
engineering applications. The major classes of polymers are briefly discussed with regard to …

Rational design of biodegradable thermoplastic polyurethanes for tissue repair

C Xu, Y Hong - Bioactive Materials, 2022 - Elsevier
As a type of elastomeric polymers, non-degradable polyurethanes (PUs) have a long history
of being used in clinics, whereas biodegradable PUs have been developed in recent …

Synthesis and characterization of degradable polyurethane elastomers containing an amino acid-based chain extender

GA Skarja, KA Woodhouse - Journal of Biomaterials Science …, 1998 - Taylor & Francis
Degradable polyurethane elastomers were synthesized using a diester chain extender. The
chain extender was synthesized by a diesterification reaction between L-phenylalanine and …

Development of biodegradable crosslinked urethane-doped polyester elastomers

J Dey, H Xu, J Shen, P Thevenot, SR Gondi… - Biomaterials, 2008 - Elsevier
Traditional crosslinked polyester elastomers are inherently weak, and the strategy of
increasing crosslink density to improve their mechanical properties makes them brittle …