Pseudomonas aeruginosa infection is a serious complication in patients with cystic fibrosis
and in immunocompromised individuals. Here we show that P. aeruginosa infection triggers …

Recent studies indicate that distinct membrane microdomains, also named lipid rafts, and
ceramide play an important role in infectious biology. Ceramide forms larger ceramide …

Microbial lung infections are the major cause of morbidity and mortality in the hereditary
metabolic disorder cystic fibrosis, yet the molecular mechanisms leading from the mutation …

Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid …

Distinct domains in the cell membrane, termed rafts, emerge as central for the infection of
mammalian cells by many pathogens. Rafts consist of sphingolipids and cholesterol that …

We recently demonstrated that the accumulation of ceramide in Cftr-deficient epithelial cells
is important for the pathophysiology of CF. However, the role of ceramide in other lung cells …

Chronic and persistent lung infections cause the majority of morbidity and mortality in
patients with cystic fibrosis (CF). Galactosyl ceramide has been previously shown to be …

Sphingolipids form a broad class of lipids with diverse functions ranging from membrane
constituents to intracellular second messengers and extracellular mediators. They can be …

Cell-surface heparan sulphate proteoglycans (HSPGs) are ubiquitous and abundant
receptors/co-receptors of extracellular ligands,, including many microbes,,,,,,,. Their role in …

Bacterial quorum-sensing autoinducers are small chemicals released to control microbial
community behaviours. N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the …