Triple dissociation of attention and decision computations across prefrontal cortex

LT Hunt, WMN Malalasekera, AO de Berker… - Nature …, 2018 - nature.com
Naturalistic decision-making typically involves sequential deployment of attention to choice
alternatives to gather information before a decision is made. Attention filters how information …

Value dynamics affect choice preparation during decision-making

ZZ Balewski, TW Elston, EB Knudsen, JD Wallis - Nature neuroscience, 2023 - nature.com
During decision-making, neurons in the orbitofrontal cortex (OFC) sequentially represent the
value of each option in turn, but it is unclear how these dynamics are translated into a choice …

Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making

MC Aoi, V Mante, JW Pillow - Nature neuroscience, 2020 - nature.com
Recent work has suggested that the prefrontal cortex (PFC) plays a key role in context-
dependent perceptual decision-making. In this study, we addressed that role using a new …

Choice-relevant information transformation along a ventrodorsal axis in the medial prefrontal cortex

DJN Maisson, TV Cash-Padgett, MZ Wang… - Nature …, 2021 - nature.com
Choice-relevant brain regions in prefrontal cortex may progressively transform information
about options into choices. Here, we examine responses of neurons in four regions of the …

Hierarchical reasoning by neural circuits in the frontal cortex

M Sarafyazd, M Jazayeri - Science, 2019 - science.org
INTRODUCTION Research on the neurobiology of decision-making has emerged as a fertile
ground for integrating cognitive, systems, computational, and, more recently, circuit and …

Prefrontal mechanisms combining rewards and beliefs in human decision-making

M Rouault, J Drugowitsch, E Koechlin - Nature Communications, 2019 - nature.com
In uncertain and changing environments, optimal decision-making requires integrating
reward expectations with probabilistic beliefs about reward contingencies. Little is known …

Decoding subjective decisions from orbitofrontal cortex

EL Rich, JD Wallis - Nature neuroscience, 2016 - nature.com
When making a subjective choice, the brain must compute a value for each option and
compare those values to make a decision. The orbitofrontal cortex (OFC) is critically involved …

Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice

SE Cavanagh, JD Wallis, SW Kennerley, LT Hunt - elife, 2016 - elifesciences.org
Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-
guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates …

A category-free neural population supports evolving demands during decision-making

D Raposo, MT Kaufman, AK Churchland - Nature neuroscience, 2014 - nature.com
The posterior parietal cortex (PPC) receives diverse inputs and is involved in a dizzying
array of behaviors. These many behaviors could rely on distinct categories of neurons …

Dynamics of neural population responses in prefrontal cortex indicate changes of mind on single trials

R Kiani, CJ Cueva, JB Reppas, WT Newsome - Current Biology, 2014 - cell.com
Decision making is a complex process in which different sources of information are
combined into a decision variable (DV) that guides action [1, 2]. Neurophysiological studies …