Homeostasis and maturation of the mammalian intestinal epithelium are preserved through
strict regulation of cell proliferation, apoptosis, and differentiation, but the exact mechanism …

The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …

Abstract c-Jun N-terminal kinases (JNKs) contribute to immune signaling but their functional
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …

Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer.
We show here that the JNK MAP kinase pathway and one of its most important substrates …

Background & Aims Paneth cells secrete antimicrobial proteins including lysozyme via
secretory autophagy as part of the mucosal protective response. The ELAV like RNA-binding …

Inhibition of growth of the intestinal epithelium, a rapidly self-renewing tissue, is commonly
found in various critical disorders. The RNA-binding protein HuR is highly expressed in the …

Food digestion requires the cooperation of different digestive organs. The differentiation of
digestive organs is crucial for larvae to start feeding. Therefore, during digestive …

The intestinal epithelium is a rapid self-renewal and regenerated tissue of which the
structural integrity is beneficial for maintaining health. The integrity of intestinal epithelium …

Background Conditional deletion of the tumour suppressor gene Apc within the murine
intestine results in acute Wnt signalling activation. The associated over-expression of a …

Occludin is a transmembrane tight junction (TJ) protein that plays an important role in TJ
assembly and regulation of the epithelial barrier function, but the mechanisms underlying its …