Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

[HTML][HTML] Actinobacteria in natural products research: Progress and prospects

PA Jose, A Maharshi, B Jha - Microbiological Research, 2021 - Elsevier
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

Genomic basis for natural product biosynthetic diversity in the actinomycetes

M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Cryptic or silent? The known unknowns, unknown knowns, and unknown unknowns of secondary metabolism

PA Hoskisson, RF Seipke - MBio, 2020 - Am Soc Microbiol
Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …

[HTML][HTML] Microbiological and molecular insights on rare Actinobacteria harboring bioactive prospective

DH Amin, NA Abdallah, A Abolmaaty, S Tolba… - Bulletin of the National …, 2020 - Springer
Background Actinobacteria is as a group of advanced filamentous bacteria. Rare
Actinobacteria are of special interest as they are rarely isolated from the environments. They …

[HTML][HTML] Concepts and methods to access novel antibiotics from actinomycetes

JJ Hug, CD Bader, M Remškar, K Cirnski, R Müller - Antibiotics, 2018 - mdpi.com
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

[HTML][HTML] Molecular and biotechnological aspects of secondary metabolites in actinobacteria

R Salwan, V Sharma - Microbiological research, 2020 - Elsevier
The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

A roadmap for natural product discovery based on large-scale genomics and metabolomics

JR Doroghazi, JC Albright, AW Goering, KS Ju… - Nature chemical …, 2014 - nature.com
Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose
systematic study is complicated by numerous repetitive motifs. By combining several metrics …

Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum

M Ventura, C Canchaya, A Tauch… - Microbiology and …, 2007 - Am Soc Microbiol
Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …