The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …

We survey the historical development of scientific knowledge surrounding Vitamin B3, and
describe the active metabolite forms of Vitamin B3, the pyridine dinucleotides NAD+ and …

Background Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous coenzyme involved
in electron transport and a co-substrate for sirtuin function. NAD+ deficiency has been …

Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms,
raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan …

Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …

More than a century after discovering NAD+, information is still evolving on the role of this
molecule in health and diseases. The biological functions of NAD+ and NAD+ precursors …

Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …