[HTML][HTML] A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …

Galanin–25 years with a multitalented neuropeptide: Galanin and spinal pain mechanisms: Where do we stand in 2008?

XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Cellular and Molecular Life …, 2008 - Springer
Since the discovery of galanin in 1983, one of the most frequently mentioned possible
physiological functions for this peptide is spinal pain modulation. This notion, initially based …

Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
The neuropeptide galanin is widely expressed in the nervous system and has an important
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …

Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications

XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …

Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

RP Hulse, LF Donaldson, D Wynick - Molecular Pain, 2012 - journals.sagepub.com
Background: Galanin is expressed in a small percentage of intact small diameter sensory
neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of …

Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models

Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …

Galanin and spinal pain mechanisms: past, present, and future

XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Galanin, 2010 - Springer
Since the discovery of galanin in 1983, one of the most frequently suggested physiological
function for this peptide is pain modulation at the level of the spinal cord. This notion, initially …

The participation of galanin in pain processing at the spinal level

HX Liu, T Hökfelt - Trends in pharmacological sciences, 2002 - cell.com
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …

Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

RP Hulse, D Wynick, LF Donaldson - Molecular pain, 2011 - journals.sagepub.com
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice

RJP Pope, FE Holmes, NC Kerr, D Wynick - Molecular Pain, 2010 - journals.sagepub.com
The neuropeptide galanin is widely expressed in both the central and peripheral nervous
systems and is involved in many diverse biological functions. There is a substantial data set …